Renowned Neuroscientist Dr. Alvaro Cruz (Joaquím De Almeida) returns home from a lecture in Paris, heartbroken and disillusioned. In his absence, his mother has succumbed to Alzheimer's disease. Nothing that his research or science could do could stop this from happening.He decides to take some time off work and reconnect with the love of music that he shared with his mother. While finding solace in the music that permeates New Orleans' French Quarter, he hears the mesmerizing voice of Una Vida (Aunjanue Ellis) for the first time. After repeat visits to hear her sing, he discovers that she is suffering from Alzheimer's disease and that her unconventional family cannot cope with her declining health.